ABSTRACT
The insidious onset of cholangiocarcinoma and the lack of early diagnosis markers have made most patients diagnosed with cholangiocarcinoma in the advanced stage of the disease. At present, surgical treatment is the first choice for patients with cholangiocarcinoma, but surgery also faces problems such as high risks and many difficulties. Recent studies have found that long non-coding RNA (lncRNA) and circular RNA (circRNA) have the functions of regulating the cell proliferation, metastasis, invasion, epithelial-mesenchymal transition and drug resistance of cholangiocarcinoma. This article aims to review the potential regulatory role of lncRNA and circRNA in the occurrence and development of cholangiocarcinoma, in order to provide clinical references for the early diagnosis, targeted therapy and patient's prognosis evaluation of cholangiocarcinoma.
ABSTRACT
Long non-coding RNAs (lncRNAs) are a kind of transcripts which are longer than 200nt and have not protein-coding ability due to the lack of an open reading frame. However, lncRNAs can be involved in tumorigenesis and progression in various ways at the transcriptional and post-transcriptional levels. Bladder cancer associated transcript 1 (BLACAT1) as a lncRNA located on human chromosome 1q32.1, is ectopic expression in various tumors (bladder cancer, gastric malignant tumor, lung carcinoma, et al) and can regulate tumor cell proliferation, anti-apoptosis, invasion and metastasis by different mechanisms leading to occurrence and development of tumors. In this review, we summarized current studies of the functions and mechanisms of BLACAT1 in malignant tumors.
ABSTRACT
reference index of lymph node in central region.